MABALL - 500MG(Anti Cancer Drug)
MABALL - 500MG(Anti
Cancer Drug)
DESCRIPTION
Maball 500mg is a anticancer medicine which prevents
the growth and spread of cancer cells in the body, the main ingredient which is
used as. Maball will help to prevent the Non-
Hodgkins lymphoma or chronic lymphocytic and with combination with another
anticancer drugs like methotrexate is used for rheumatoid arthritis symptoms in
adult treatment. Maball 500mg with steroid regimen combination is given for the treatment
of some rare disorders which cause blood vessels and other tissues inflammation
in the body.
INDICATION
Maball 500mg and hyaluronidase human injection are
given alone or combination with another drugs to treat certain types of
non-Hodgkin's lymphoma and chronic lymphocytic leukemia (cancer start in
WBC). Maball 500mg injection combination with
methotrexate (Otrexup, Rasuvo, Xatmep, others) is also indicated for the
treatment rheumatoid arthritis symptoms in adults that have been already
treated with a some type of regimen knowns as tumor necrosis factor (TNF)
inhibitor. Maball 500mg is a type in a
classification of drugs called monoclonal antibodies. Maball
500mg is used to killing cancer cells to treat NHL , CLL,
rheumatoid arthritis, granulomatosis with polyangiitis, and microscopic
polyangiitis by inhibiting the activity of the immune system parts that can
injury the joints, veins, and other blood vessels and cause organs (heart and
lungs) damage.
DOSAGE
Maball 500mg injection is usually used to administrate only via
intravenous infusion not by IV push or bolus.
BEFORE EACH INFUSION THE DRUG IS PREMEDICATE :
First infusion: Starting
treatment rate of 50 mg/hr is administer , in not showing infusion toxicity,
rate raised up to 50 mg/hr increments at intervals of 30 min and max of 400
mg/hr. Successive infusion: initial at rate of 100 mg/hr, in not showing
infusion toxicity, rate raised upto 100 mg/hr increments at intervals of 30 min
and max of 400 mg/hr. While combination with CHOP chemotherapy the Maball 500mg injection has not been
given. Hence Premedication with corticosteroids must be considered.
LOW GRADE OR FOLLICULAR NON-HODGKINS LYMPHOMA :
The drug Maball Dose
is 375 mg/m2 as an IV infusion. Once weeks for 4 or 8 doses administrated for Relapsed
treatment Once weekly for 4 doses administrated for Retreatment for relapsed.
Previously untreated: administer on day 1 of each cycle of chemotherapy, up to
8 doses. In complete or partial response of patient, start with 8 weeks for
maintenance following Maball 500mg in combination with
chemotherapy completed then administer 8weeks for 12 doses as a single agent.
Once weekly for 4 doses at intervals of 6 months and max of 16 dose for Non – progression
(following CVP chemotherapy completion 6 – 8 cycles): On day 1 each cycle of
chemotherapy up to 8 infusions for Diffuse large B- cell NHL
CHRONIC LYMPHOCYTIC LEUKEMIA :
Before starting of FC
chemotherapy, dose recommended is 375 mg/m2 followed 500 mg/m2 on day 1 of 2-6
cycles every 28 days.
MECHANISM OF ACTION:
Maball 500mg is a type of class called as monoclonal
antibody. A new type of "targeted" cancer treatment and an integral
part of the body's immune system. Naturally the body fused to antibodies in
along with an antigen which has entered the body and attack the antigen for
destruction by the immune system. Monoclonal antibiotics which only targeted by
an essential cells only, they may cause less toxicity to healthy cell and it is
prescribed treatment given only for cancers in which antigens (and the
respective antibodies) have been already identified. Maball 500mg injection works by linking
to the CD20 antigen on normal and malignant B-cells. Hence natural immune
security of body are initiated to attach and kill the marked B-cells. Young
cells (stem cells) in the bone marrow which will develop into the various cell
types and do not have the CD20 antigen. After treatment CD20 antigen allows
healthy B-cells to multiply.
ADMINISTRATION:
Take an amount Maball 500mg injection is administer and
diluted to final concentration of 1 mg/ml upto 4 mg/ml as infusion (containing
either 0.9% Nacl or 5% dextrose in water). Gently Invert the bag and mix the
solution. Discard unused drug left in vial.
OVERDOSAGE:
If over dose occurs seek
immediately to the emergency department or poison control help line. please
consult the doctor for further clarification.
PRECAUTIONS
Allgeric condition
against Maball 500mg or any other medication
inform your doctor. Information about past medical history used which include
in prescription, non-prescription, vitamins &supplements , nutritional
products just inform the doctor. While using Maball
500mg do not take any vaccination or immunization without
taking advice from doctors. Avoid use of Maball 100mg if you are pregnant. It
will harm the baby unborn, while using Maball 500mg injection use correct birth
control to prevent pregnancy and for at least 2 weeks after your treatment
ends. Maball 500mg may affect the ability to
have children in women. Inform your doctor if you planning to pregnant. It is
unknown whether Maball 500mg passes into breast milk ,
avoid breast-feed while on Maball
500mg treatment.
CONTRAINDICATION
Hypersensitivity or
murine proteins. Active severe infectons in rheumatoid arthritis Uncontrolled
cardiac disease.
MISSED DOSE
If a dose missed then
have the Maball 500mg injection soon
you remembered, if next dose time reach then leave the missed dose and follow
the normal schedule. Do not have 2 dose at a same time. Please consult with
doctor for further details.
DRUG INTERACTION
Maball 500mg drug interaction has limited data is
available at present.Interation with fludarabine or cyclophosphamide have no
effects in pharmacokinetics in CLL patients. Maball combination
with methotrexate had no effects in pharmacokinetics.
STORAGE
Store the drug Maball at
2℃ – 3℃ Keep away from the childerns Use the drug before expiry date Protected
from direct sunlight and Do not freeze or shake. Discard the unused drug by
asking the advice from doctor or pharmacist.
SIDE EFFECTS
Common effects: fever
and chills (flu lik symptoms)
Less common side effects: Weakness; nausea ; headache; cough ; dyspnea ; pharyngitis
Less common side effects: Weakness; nausea ; headache; cough ; dyspnea ; pharyngitis
LACTATION:
The Maball
500mg drug excretion into human milk is unknown. Because
the drug is a higher protein molecule and has no information is available.
Women should not breast feed during Maball 500mg injection treatment and
till12 months following last dose.
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