RITUXIREL - 500MG(ANTI CANCER DRUG)
RITUXIREL - 500MG(ANTI CANCER DRUG)
DEFINES:
- Rituxirel 500mg is
an anticancer medicine which prevents the growth and spread of cancer
cells in the body.
- Rituxirel will
help to prevent the Non- Hodgkin’s lymphoma or chronic lymphocytic and
with combination with another anticancer drug like methotrexate is used
for rheumatoid arthritis symptoms in adult treatment.
- Rituxirel 500mg injection with steroid regimen combination is given for the
treatment of some rare disorders which cause blood vessels and other
tissues inflammation in the body.
INDICATIONS
- Rituxirel 500mg and hyaluronidase human injection are given alone
or combination with other drugs to treat certain types of non-Hodgkin's
lymphoma and chronic lymphocytic leukemia (cancer start in WBC).
- Rituxirel 500mg injection combination with methotrexate (Otrexup, Rasuvo,
Xatmep, others) is also indicated for the treatment rheumatoid arthritis
symptoms in adults that have been already treated with a some type of
regimen knowns as tumor necrosis factor (TNF) inhibitor. Rituxirel 100mg
is a type in a classification of drugs called monoclonal antibodies.
- Rituxirel is
used to killing cancer cells to treat NHL, CLL, rheumatoid arthritis,
granulomatosis with polyangiitis, and microscopic polyangiitis by
inhibiting the activity of the immune system parts that can injury the
joints, veins, and other blood vessels and cause organs (heart and lungs)
damage.
DOSAGE
Rituxirel 500mg injection is usually used to administrate only via
intravenous infusion not by IV push or bolus:
Before Each Infusion the Drug Is Premediate:
First infusion:
Starting treatment rate of 50 mg/hr. is administer, in not showing infusion toxicity, rate raised up to 50 mg/hr. increments at intervals of 30 min and max of 400 mg/hr.
Successive infusion:
Starting treatment rate of 50 mg/hr. is administer, in not showing infusion toxicity, rate raised up to 50 mg/hr. increments at intervals of 30 min and max of 400 mg/hr.
Successive infusion:
- Initial at rate of 100 mg/hr., in not showing infusion
toxicity, rate raised up to 100 mg/hr. increments at intervals of 30 min
and max of 400 mg/hr.
- While combination with CHOP chemotherapy the
injection Rituxirel 500mg has not been given.
Hence Premedication with corticosteroids must be considered.
Low grade or follicular
non-Hodgkin’s lymphoma:
- The drug Rituxirel 500mg Dose is 375 mg/m2
as an IV infusion.
- Once weeks for 4 or 8 doses administrated for Relapsed
treatment
- Once weekly for 4 doses administrated for Retreatment
for relapsed.
ADMINISTRATION :
Take an amount Rituxirel
500mg injection is administer and diluted to final concentration of 1 mg/ml
up to 4 mg/ml as infusion (containing either 0.9% Nacl or 5% dextrose in
water). Gently Invert the bag and mix the solution. Discard unused drug left in
vial.
OVERDOSAGE:
If an Rituxirel
500mg overdose occurs seek immediately to the emergency
department or poison control help line. Please consult the doctor for further
clarification.
MECHANISM OF ACTION
- Rituxirel is a type of class called as
monoclonal antibody. A new type of "targeted" cancer treatment
and an integral part of the body's immune system. Naturally the body fused
to antibodies in along with an antigen which has entered the body and
attack the antigen for destruction by the immune system.
- Monoclonal antibiotics which
only targeted by an essential cell only, they may cause less toxicity to
healthy cell and it is prescribed treatment given only for cancers in
which antigens (and the respective antibodies) have been already
identified.
- Rituxirel
500mg injection works by linking to the
CD20 antigen on normal and malignant B-cells. Hence natural immune
security of body are initiated to attach and kill the marked B-cells.
Young cells (stem cells) in the bone marrow which will develop into the
various cell types and do not have the CD20 antigen. After treatment CD20 antigen
allows healthy B-cells to multiply.
PRECAUTIONS
- Allergic condition
against Rituxirel 500mg or any other
medication inform your doctor. Information about past medical history used
which include in prescription, non-prescription, vitamins
&supplements, nutritional products just inform the doctor.
- While using Rituxirel 500mg do not take any
vaccination or immunization without taking advice from doctors.
- Avoid use of Rituxirel 500mg injection if
you are pregnant. It will harm the baby unborn, while using Rituxirel 500mg use correct birth
control to prevent pregnancy and for at least 2 weeks after your treatment
ends.Rituxirel may affect the ability to
have children in women. Inform your doctor if you planning to pregnant.
- It is unknown whether Rituxirel 500mg passes into breast
milk, avoid breast-feed while on Rituxirel 500mg treatment.
STORAGE
- Store the drug Rituxirel 500mg at 2℃ – 3℃
- Keep away from the childerns
- Use the drug Rituxirel 500mg injection before
expiry date
- Protected from direct sunlight and Do not freeze or
shake.
- Discard the unused drug by asking the advice from
doctor or pharmacist.
DRUG INTERACTION
- Rituxirel 500mg drug interaction has limited data is available at
present.
- Interaction with fludarabine or cyclophosphamide have
no effects in pharmacokinetics in CLL Rituxirel 500mg combination with methotrexate
had no effects in pharmacokinetics.
CONTRAINDICATION
- Hypersensitivity or murine proteins.
- Active severe infections in rheumatoid arthritis
- Uncontrolled cardiac disease.
MISSED DOSE
- If a dose missed then have the drug Rituxirel 500mg soon you
remembered, if next dose time reach then leave the missed dose and follow
the normal schedule.
- Do not have 2 doses at a same time. Please consult with
doctor for further details.
SIDE EFFECTS
- Common effects: fever and chills (flu lik symptoms)
- Less common side effects: Weakness; nausea ; headache; cough ; dyspnea ; pharyngitis.
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