Crizalk (Crizotinib) 200mg Capsule: View Uses, Price & side effects|Apple pharmaceuticals

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Crizalk (Crizotinib) 200mg Capsule: View Uses, Price & side effects|Apple pharmaceuticals


  • Crizalk 200mg belongs to type of tyrosine kinase inhibitor. Kinases are enzymes which are included in many functions, involving cell development and reproduction.
  • Crizalk 200mg is made specifically for the treatment of a type of lung cancer in which ALK is overactive due to an abnormality in the ALK gene.
Crizalk 200mg , Crizalk 200mg capsule

INDICATION

  • Crizalk 200mg capsule is indicated for the therapy of patients having metastatic non-small cell lung cancer.

DOSAGE MODIFICATION

  • Crizalk 200mg taken orally once daily for Second dose reduction
  • Permanently discontinue if unable to tolerate Crizalk 200mg taken orally once daily.

MECHANISM

  • Particularly, Crizotinib prevents anaplastic lymphoma kinase (ALK), hepatocyte growth factor receptor (HGFR, c-MET), and Recepteurd'OrigineNantais (RON).
  • Malformations in the ALK gene result by mutations or translocations may leads expression of oncogenic fusion proteins. somepatients with NSCLC, they have the EML4-ALK gene.
  • Crizotinib inhibits ALK tyrosine kinase which essentially results in decreasedproliferation of cells which carry the genetic mutation and tumour survivability.

ADME

  • Maximum serum concentration is 4 to 6 hours and bioavailability were 43%.
  • Volume of distribution is 1772L and plasma protein bounding is 91%
  • Crizalk metabolised by CYP3A4 and CYP3A5
  • Crizalk 200mg is eliminated via feces 63% and 22% via urine and half -life is 42 hours
Dosage and administration :
  • Select patients for the treatment with Crizalk based on ALK or ROS1 presences in tumor specimens
  • The usual dosage of Crizalk is 250mg orally twice in a day
  • Administer the Crizalk dose with or without food, until disease progression.

PRECAUTION

  • Before using Crizalk 200mg in some condition, consult with doctor.
  • while treatment with Crizalk will causes Interstitial lung disease/pneumonitis.
  • QT interval prolongation
  • Bradycardia
  • Severe visual loss
Embryo-fetal toxicity:
  • based on mechanism action the drug will cause risk to foetus

DRUG INTERACTION

  • Crizalk 200mg Combination with strong or moderate CYP3A4 inhibitors will increase Crizalk plasma concentration
  • Crizalk 200mg capsule concomitant use with strong CYP3A inducers will decrease Crizalk plasma concentration
  • Crizalk 200mg Interaction with CYP3A substrates will increase plasma concentration of CYP3A substrates
  • Do not use combination with bradycardia causing drugs

CONTRAINDICATION

  • None
Crizalk 200mg , Crizalk 200mg capsule

MISSED DOSE

  • If the patient vomits after taking a dose of Crizalk 200mg capsule or missed to take a dose, then should not to take an extra dose, but to take the next dose at the regular time, skip the missed dose.

STORAGE

  • Store at 20℃ to 25℃

SIDE EFFECTS

Crizalk is caused some side effects as follows :

  • Infection increased
  • Breathlessness
  • Eyesight changes
  • Bowel changes
  • Feeling sick
  • Swelling of hands and feet’s
  • Decreased appetite
  • Fatigue
  • Liver changes
  • Skin rash
  • bradycardia.

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